Urticaria pigmentosa - Pigmentna Urtikarija
Pigmentna Urtikarija (Urticaria pigmentosa) je najčešći oblik kožne mastocitoze. To je rijetka bolest uzrokovana prekomjernim brojem mastocita u koži koji stvaraju osip ili lezije na koži kada su nadraženi. Crvene ili smeđe mrlje često se vide na koži, obično oko prsa, čela i leđa. Ove mastocite, kada su nadražene (npr. trljanjem kože, izlaganjem toplini), proizvode previše histamina, izazivajući alergijsku reakciju koja dovodi do koprivnjače lokalizirane na području iritacije, koja se ponekad naziva "Darierovim znakom".
☆ U rezultatima Stiftung Warentest iz Njemačke za 2022., zadovoljstvo potrošača s ModelDermom bilo je samo malo niže nego s plaćenim konzultacijama o telemedicini.
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Mastocytosis je stanje u kojem postoji višak mastocita, koji se često nalaze u različitim dijelovima tijela poput kože, koštane srži i probavnog sustava. Prema Svjetskoj zdravstvenoj organizaciji (WHO) , cutaneous mastocytosis se može kategorizirati u tri glavne vrste. Prvi tip (mastocytomas) sastoji se od pojedinačnih ili nekoliko (≤3) lezija. Drugi tip (urticaria pigmentosa) uključuje višestruke lezije, obično u rasponu od više od 10 do manje od 100. Posljednji tip pokazuje široku zahvaćenost kože. Urticaria pigmentosa je najčešći oblik kožne mastocitoze kod djece, no može se pojaviti i kod odraslih. Obično je to bezopasno stanje koje se često popravlja tijekom adolescencije. Za razliku od mastocitoze odraslih, urticaria pigmentosa rijetko zahvaća unutarnje organe. Jedna karakteristična značajka urticaria pigmentosa je njegova tendencija da uzrokuje male, crvenkasto-smeđe ili žućkasto-smeđe mrlje ili lezije na koži, koje svrbe, obično poznate kao koprivnjača. Te se mrlje obično pojavljuju u djetinjstvu i mogu trajati cijeli život.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
6-godišnja djevojčica došla je s nekoliko tamnih mrlja koje su se najprije pojavile na tjemenu, a zatim su se proširile na lice i tijelo tijekom posljednjih šest mjeseci. Spomenula je kako se podižu, pocrvene i svrbe kad se pritisne. Nije osjetila crvenilo, povraćanje, proljev ili hripanje, a njezina osobna i obiteljska povijest bolesti nije pružila relevantne tragove. Nakon pregleda pronašli smo više tamnih mrlja na njezinom tjemenu, čelu, licu i vratu, zajedno s blago uzdignutim tamnim mrljama na prsima i leđima. Lagano trljanje mrlja uzrokovalo je njihovo oticanje i svrbež u roku od 2 minute, ali simptomi su nestali u roku od 15-20 minuta (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
